Multicenter, open-label, phase 1/2 trial Cisplatin ineligible local advanced/metastatic urothelial carcinoma Enfortumab vedotin +pembrolizumab q21 (n=45)

20 May

Colorectal Cancer

New Protocl: Trifluridine-Tipiracil and Bevacizumab in Metastatic Colorectal Cancer

Phase III, randomized, open-label trial (SUNLIGHT) Adult patients who had received no more than two previous chemotherapy regimens for the treatment of advanced colorectal cancer

14 Apr

Uterine Cancer

New Protocol: Pembrolizumab with Chemotherapy in Advanced Endometrial Cancer

Phase III, randomized, double-blind, placebo-controlled Advanced-stage, metastatic, or recurrent endometrial cancer of any histologic subtype except for carcinosarcoma Pembrolizuma

15 Mar

Breast Cancer

New Drug: Elacestrant for ER+ Breast Cancer

International, multicenter, randomized, open-label, phase III (EMERALD) ER-positive/HER2-negative advanced breast cancer who had one-two lines of endocrine therapy, required pretre

16 Jul

GastroEsophageal Cancer

New Protocol: Perioperative FLOT with Trastuzumab and Pertuzumab for her2-Positive Gastroesophageal Cancer

Multicenter, randomized phase II/III trial HER 2–positive, >= clinical tumor 2 or clinical nodal–positive resectable EGA Four pre and postoperative cycles of either FLOT alone

20 Sep

Acute myeloid leukemia

New Drug: Enasidenib for IDH2 Mutant AML

International, multicenter, randomized, open-label, phase 3 trial Age ≥60 years, IDH2 gene mutated, de novo or secondary AML Previously 2 or 3 prior AML- directed therapies Enasi

20 May

Biliary Tract Cancer

New Protocol: Pembrolizumab with CISplatin and Gemcitabine in Metastatic Biliary Tract Cancer

Phase III, double-blind, randomized, controlled, multicenter, open-label trial (KEYNOTE-966) Previously untreated, unresectable, locally advanced or metastatic biliary tract cancer

24 Jun

Ovarian Cancer

New Drug: Mirvetuximab Soravtansine in Advanced Ovarian Cancer

A Phase III, Randomized, Open-label trial (MIRASOL) Platinum-resistant, advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate recep

20 Nov

GastroEsophageal Cancer

New Reference: DOCEtaxel, OXALIplatin, Capecitabine in Locally Advanced Gastric Cancer

Randomized, open-label, phase 3 trial Potentially resectable, locally advanced cT3-4 gastric adenocarcinoma in patients younger than 60 years Neoadjuvant Docetaxel, Oxaliplatin, Ca

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