Phase II/III, randomized, open-label study Cisplatin-ineligible patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) Docetaxel-RT (n=180) vs. RT (n=176)

10 Jan

Chronic Lymphocytic Leukemia

New Reference: Zanubrutinib for R/R CLL

Phase III, randomized, open-label study (ALPINE) Relapsed or refractory CLL/SLL Zanubritinib (n=327) vs. İbrutinib (n=325)

15 Mar

Colorectal Cancer

New Drug: Adagrasib with/without Cetuximab in kRAS G12C Mutant Colorectal Cancer

Phase I-II, nonrandomized, open-label trial Pretreated metastatic colorectal cancer patients with KRAS G12C mutation Adagrasib + Cetuximab (n=32) and Adagrasib (n=44)

10 Jan

Melanoma

New Protocol: Atezolizumab with Vemurafenib and Cobimetinib in Metastatic Melanoma

Phase III, multicenter, randomized, double-blind trial Previously untreated unresectable stage IIIc or stage IV melanoma Atezolizumab (n=256) vs. PBO + vemurafenib + cobiventinib (

10 Jan

Ovarian Cancer

New Drug: Mirvetuximab Soravtansine in FRalpha Positive Ovarian Cancer

Single-arm, Phase-3 trial (SONAYA) Platinum-resistant epithelial ovarian cancer (up to three prior lines of systemic therapy; all patients were required to have received bevacizuma

10 Jan

Acute myeloid leukemia

New Drug: Enasidenib in IDH2 Mutant AML

Phase III, randomized, open-label study Patients aged ≥60 years with late-stage, mutant-IDH2 acute myeloid leukemia (AML) relapsed/refractory (R/R) to 2 or 3 prior AML-directed t

10 Jan

Non-Small Cell Lung Cancer

New Indication: Durvalumab with Tremelimumab in Metastatic NSCLC

Phase III, randomized, three-arm, open-label study (POSEIDON) Previously untreated mNSCLC Arm A: (T+C+CT) Tremelimumab 75 mg plus durvalumab 1,500 mg and chemotherapy for up to fou

10 Jan

Non-Small Cell Lung Cancer

New Protocol: Cemiplimab with Chemotherapy in NSCLC

Double-blind, placebo-controlled, phase 3 study Untreated advanced or metastatic NSCLC Group A (Cemiplimab + chemotherapy (n=312)) vs. group B (chemotherapy alone (n=154))

10 Jan

Follicular Lymphoma

New Drug: Mosunetuzumab for R/R Follicular Lymphoma

Single-arm, multicenter, phase 2 study Relapsed or refractory to two or more previous lines of treatment Mosunetuzumab q21 days (n=90)

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