Phase III, randomized, open-label trial (monarchE) Hormone receptor-positive, HER2-negative, node-positive, early breast cancer at a high risk of recurrence Abemaciclib + ET (n=280

16 Mar

Nervous System Tumor

New Indication: Dabrafenib and Trametinib in bRAF V600E Mutant Glioma

Open-label, single-arm, phase 2, basket trial BRAFV600E mutation-positive high- low-grade glioma Prior radiotherapy and chemotherapy or chemoradiotherapy for high grade glioma Dabr

24 Jun

Hepatocellular Carcinoma

New Indication: Adjuvant Atezolizumab – Bevacizumab in HCC

Phase III, randomized, controlled, multicenter, open-label trial (İMbrave050) HCC pts at high risk of recurrence following resection or ablation. Atezolizumab + Bevacizumab q21 (n

15 Mar

Mantle cell lymphoma

New Drug: Pirtobrutinib in Mantle Cell Lymphoma

Open-label, multicenter, single-arm trial (BRUIN) Mantle cell lymphoma previously treated with a BTK inhibitor Pirtobrutinib (n=120)

20 Aug

Diffuse Large B Cell Lymphoma

New Drug: Glofitamab in Large B-Cell Lymphoma

Phase I-II, open-label, multicenter study Relapse or refractory large cell lymphoma Glofitamab (n=132)

20 May

Skin Cancer (Other than Melanoma)

New Drug: Retifanlimab in Advanced Merkel Cell Carcinoma

Open-label, multicenter, single-arm, phase 2 study Treatment naïve metastatic or recurrent locally advanced MCC Retifanlimab q28 (n=65)

20 May

Breast Cancer

New Reference: Trastuzumab Deruxtecan for her2-Positive Breast Cancer

Phase III, randomized, controlled, multicenter, open-label trial (DESTINY-Breast-02) HER2-positive, previously received trastuzumab-emtansine, unresectable or metastatic breast can

24 Jun

Soft Tissue Sarcoma

New Protocol: Nivolumab and Trabectedin in Advanced Soft Tissue Sarcoma

Prospective, explorative, two-group, non-randomized, phase II trial (NITraSarc) Advanced, previously treated lipo-leiomyosarcoma (Group A: GA) (n=43) and non-L-sarcomas (Group B:

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