J Clin Oncol 2015;33(6):594-601 Kaufman PA Phase III open-label randomized study of eribulin mesylate versus capecitabine in patients with locally advanced or metastatic breast can

21 Jun

Small Cell Lung Cancer

New Indication: Repotrectinib for NTRK-Fusion Positive Solid Tumors

Advanced NTRK-fusion+ solid tumors (TRIDENT-1) TKI-naive (n=40) and TKI-pretreated (n=48)

21 Jun

Non-Small Cell Lung Cancer

New Drug: Repotrectinib for ROS1-fusion positive NSCLC

Phase 1-2 single-arm (TRIDENT-1) ROS1-fusion positive advanced NSCLC TKI-naive (n=71) - prior-TKI (n=56)

21 Jun

Uterine Cancer

New Protocol: Durvalumab with CARBOplatin and PACLitaxel for Endomterial Cancer

Randomized, double-blind phase III (DUO-E) Newly diagnosed FIGO Stage III/IV or recurrent endometrial cancer of epithelial histology Carbo/paclitaxel x 6 => Placebo maintenance (I)

14 Apr

Uterine Cancer

New Indication: Trastuzumab Deruxtecan for her2-Expressing Advanced Uterine Cancer

Phase II, multicenter, single-arm study (STATICE) Pretreated advanced or recurrent HER2-expressing UCS Trastuzumab Deruxtecan: HER 2:1+ (low group, n=10) vs. HER 22+ (high grou

14 Apr

Head and Neck Cancer

New Indication: Axitinib and Avelumab for Adenoid Cystic Carcinoma

• Open-label,single-arm, phase 2 study Pretreated metastatic or recurrent ACC Axitinib + Avelumab q28 (n=28)

15 Mar

Waldenstrom macroglobulinemia

New Reference: Bortezomib, Rituximab, Cyclophosphamide for Waldenstrom

Prospectively Randomized , phase 3 trial Treatment naïve Waldenström's macroglobulinemia (WM) Bortezomib, dexamethasone, rituximab, and cyclophosphamide (B-DRC ) vs. DRC

10 Jan

Multiple Myeloma

New Drug: Teclistamab in R/R Multiple Myeloma

Single-arm, multi-cohort, open-label, multicenter, phase 1/2 study Relapsed or refractory myeloma after at least three therapy lines (n=165) Teclistamab sc weekly

10 Jan

Biliary Tract Cancer

New Drug: Futibatinib for Cholangicarcinoma

A single-arm, multicenter, phase 2 study Advanced/metastatic unresectable iCCA harboring FGFR2 gene fusions Disease progression after ≥1 line of systemic therapy Futibatinib 20 m

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